28/F, RT OVARIAN TUMOR

GROSS - EXTERNAL SURFACE

                                                  




                  CUT SURFACE

 SPINDLE SHAPED FIBROBLAST LIKE CELLS

               


        LEUTENIZED THECA LIKE CELLS

HYPOCELLULAR AREAS














ADDITIONAL INFORMATION:

IHC

vascular permeability factor[VPF] and vascular endothelial growth factor[VEGF] - leutinized cells

FMS like tyrosine kinase[flt-1] - small blood vessels

FISH

chromosome 12 trisomy in 13-21% of SSTs. 

 

43 F, BREAST MASS EXCISION. CLINICAL DIAGNOSIS - GIANT FIBROADENOMA

 GROSS

                                                           LEAF LIKE











10X

                                                                        40X

ADDITIONAL FACTS-

CGH and FISH analysis can be used to differentiate benign and malignant phylloids.

Most common genetic imbalances that occur in malignant phylloids are MDM2, MYC and RB1.

GRANULOSA CELL TUMOUR - OVARY

 CALL EXNER BODIES

 GROSS

 10X

 97% OF ADULT GRANULOSA CELL TUMOURS HARBOUR A SOMATIC MISSENSE MUTATION IN THE FOXL2  [FORK HEAD BOX L2] GENE.