Giant cells with PAS positive fungus

60/F, Gall bladder with stones

20/F, CYSTIC LESION PANCREAS

PAPILLAE

ROSETTE LIKE

COARSE CHROMATIN

PORTION OF PANCREAS WITH SPLEEN

CUT SURFACE

10/F, CERVICAL LYMPH NODE

RS CELL

RS CELLS WITH EOSINOPHILS

RS CELLS & EOSINOPHILS

GROSS

ASPERGILLUS NIGER

FRUITING BODIES OF ASPERGILLUS

KERATOACANTHOMA

KERATIN FILLED CRATOR

THYROID FNA

PAPILLAE

NUCLEAR PALISADING

INTRANUCLEAR INCLUSIONS

PAGET'S DISEASE OF BREAST

PAGET'S CELLS

 ADULT FILARIAL WORM IN A LYMPH NODE

MALE WITH VAS DIFFERENS

VAS DIFFERENS CONTAINING SPERMATOZOA

TWO UTERI CONTAINING OVA

FEMALE WITH DOUBLE UTERUS


ADDITIONAL FACTS:

Serological tests for detecting filariasis - IFA, ELISA(not as specific as IFA)

28/F, RT OVARIAN TUMOR

GROSS - EXTERNAL SURFACE

                                                  




                  CUT SURFACE

 SPINDLE SHAPED FIBROBLAST LIKE CELLS

               


        LEUTENIZED THECA LIKE CELLS

HYPOCELLULAR AREAS














ADDITIONAL INFORMATION:

IHC

vascular permeability factor[VPF] and vascular endothelial growth factor[VEGF] - leutinized cells

FMS like tyrosine kinase[flt-1] - small blood vessels

FISH

chromosome 12 trisomy in 13-21% of SSTs. 

 

43 F, BREAST MASS EXCISION. CLINICAL DIAGNOSIS - GIANT FIBROADENOMA

 GROSS

                                                           LEAF LIKE











10X

                                                                        40X

ADDITIONAL FACTS-

CGH and FISH analysis can be used to differentiate benign and malignant phylloids.

Most common genetic imbalances that occur in malignant phylloids are MDM2, MYC and RB1.

GRANULOSA CELL TUMOUR - OVARY

 CALL EXNER BODIES

 GROSS

 10X

 97% OF ADULT GRANULOSA CELL TUMOURS HARBOUR A SOMATIC MISSENSE MUTATION IN THE FOXL2  [FORK HEAD BOX L2] GENE.